Good Vibrations A new treatment under study by NASA-funded doctors
could reverse bone loss experienced by astronauts in space.
The familiar mantra of fitness buffs applies as much in space as it does on Earth -- perhaps more so. The bones and muscles of astronauts, freed from the familiar strains of gravity, can weaken alarmingly. Muscles atrophy relatively quickly, while bones lose mass during prolonged exposures to weightlessness.
Reducing muscle atrophy requires exercise -- and lots of it. Astronauts in space spend about two hours each day working out with the aid of exotic devices that rely on springs, elastic, and harnesses to provide resistance and mimic body weight.
Unfortunately, such "countermeasures" have not solved the problem of muscle or bone loss. It's an ongoing problem for astronauts -- and for researchers!
Above: The proper type and amount of exercise is a key to maintaining muscles and cardiovascular fitness in space. But the workouts astronauts have tried so far haven't yet solved the problem of bone or muscle loss. Image courtesy Johnson Space Center.
The same therapy, they say, might eventually be used to treat some of the millions of people who suffer from bone loss, called osteoporosis, here on Earth.
"The vibrations are very slight," notes Stefan Judex,
assistant professor of biomedical engineering at the State University
of New York at Stony Brook, who worked on the research. The plate
vibrates at 90 Hz (1 Hz = 1 cycle per second), with each brief
oscillation imparting an acceleration equivalent to one-third
of Earth's gravity. "If you touch the plate with your finger,
you can feel a very slight vibration," he added. "If
you watch the plate, you cannot see any vibration at all."
Although the vibrations are subtle they have had a profound effect on bone loss in laboratory animals such as turkeys, sheep, and rats.
Left: Vibration plates such as this one were used for experiments on bone loss involving turkeys, sheep, and rats. Pictured with the turkey is researcher Dr. Clinton Rubin. Photo credit: Cary Wolinsky. This image originally appeared in a National Geographic feature article "Surviving in Space."
In one study (published in the October 2001 issue of The
FASEB Journal), only 10 minutes per day of vibration therapy
promoted near-normal rates of bone formation in rats that were
prevented from bearing weight on their hind limbs during the
rest of the day. Another group of rats that had their hind legs
suspended all day exhibited severely depressed bone formation
rates -- down by 92% -- while rats that spent 10 minutes per
day bearing weight, but without the vibration treatment, still
had reduced bone formation -- 61% less.
These results show that the vibration treatment maintained normal bone formation rates, while brief weight bearing did not.
Clinton Rubin, a professor of biomedical engineering at SUNY
Stony Brook and principal investigator for the study, cautions
that more experiments are required before scientists can be sure
that vibration therapy is effective for people. "Animals
are different than humans," he notes. And even among humans
there are important variables, like nutrition and genetic make-up.
What works for post-menopausal women (who often suffer from osteoporosis)
might not work for astronauts in space.
In a recent "Phase I/II" clinical trial of vibration therapy, researchers applied the treatment to 60 post-menopausal women. Studies using adolescent girls with very low bone density and children with cerebral palsy are also underway.
"The early results from the research with post-menopausal
women are very encouraging -- but they are preliminary. To determine
efficacy, we will need a larger scale clinical trial that runs
for a longer period of time," Rubin says.
A broader "Phase III" clinical trial is currently being organized, which will provide a strong indication of the treatment's effectiveness for the general population of osteoporosis sufferers.
Right: The primary weight-bearing
bones -- highlighted here in purple -- are also the ones most
susceptible to weakening in space. Picture from Human Physiology
in Space, a curriculum supplement for secondary schools.
(Lujan and White)
Whether astronauts would benefit from a vibration-plate regimen is a question that can only be fully answered by conducting experiments in space, Rubin says. Such tests have been proposed, but none are scheduled yet.
Rubin hopes that future experiments will reveal not only whether
vibration therapy works, but also why. It's a bit of a
puzzle because the treatment doesn't comfortably fit within the
framework of conventional wisdom: Currently, most bone researchers
believe that the stresses placed on bones by, e.g., bearing
weight or strong physical exertion, signal the bone-building
cells through some unknown chemical trigger to fortify bones.
According to this thinking, the remedy for bone loss in space
should be exercises that duplicate stresses on our muscles and
skeletons experienced during a daily and active life on Earth.
Unfortunately, without the pull of gravity it is very difficult, if not impossible, to duplicate loads routinely experienced by our muscles and bones on Earth. The regimen of exercise that astronauts perform in space has shown some promise as a countermeasure, but not enough to protect long-voyaging astronauts from injury or bone fracture when they are re-exposed to gravity -- either here on Earth or on some other planet.
Rubin suggests that perhaps it's not only a few, large stresses placed on the skeleton that signal bone formation, but also many smaller, high-frequency vibrations applied to bones by flexing muscles during common activities such as standing or walking.
Muscles may appear to pull steadily and constantly when flexing -- like the pull of a stretched spring. But muscle contraction is more complex than that. Individual muscle cells in most skeletal muscles can't provide a sustained pull -- they can only apply a quick "twitch." To create a constant pull, the brain activates groups of muscle cells within a muscle (called "motor units") in a rapid, repeating pattern.
interior of bones isn't completely solid. Instead, it consists
of a web of mineral filaments -- called "trabeculae"
-- and cells (not shown in this micrograph). These trabeculae
provide structural rigidity while minimizing weight, like the
steel cross-members in a crane or a highway sign. Image courtesy
You can feel these subtle patterns by squatting and resting your hands on your thighs -- the slight trembling of your thigh muscles is the sequential contraction of the muscles' motor units. The frequency of such contraction ranges between 10 and 100 Hz. In comparison, the experiment with rats used a 90 Hz vibration, and the experiments with humans are using 30 Hz vibrations.
"Our hypothesis is that a key regulator of bone mass and morphology are the mechanical stimuli that come out of muscle contractions," Rubin says. "So instead of these big, intensive deformations of bone, it's basically lots and lots of little ones [that provide a major stimulus for bone growth]."
"While exercise in space may generate some of these signals, we believe that microgravity essentially extinguishes these signals during the great majority of the day, as postural activity is [markedly reduced compared to here on Earth]," he says. "The vibration treatment generates a much larger signal in this frequency range, and we believe that 10 minutes per day of this higher frequency signal is sufficient to provide a maintenance signal to bone."
Above: When future astronauts return to Earth after a long voyage to Mars and back -- all in reduced or zero gravity -- they will need strong bones to once again stride across their home planet. Vibration therapy might be the key. Painting by Pat Rawlings.
"This is a real departure from the accepted theory of how mechanical signals control bone, and it is certainly controversial," Rubin says.
Nevertheless, it might work. Good vibrations -- unexpected and controversial -- could be the key to healthy bones on Earth and beyond.
Editor's note: Exercises in space using devices that mimic body weight and exert stress on the musculoskeletal system have not yet succeeded in eliminating muscle and bone loss. However, caution researchers, the type, intensity and duration of exercise that humans perform here on Earth has not yet been duplicated in space.Web Links
NASA's Office of Physical and Biological Research -- tackling puzzles like osteoporosis through space research.
Subscribers to the FASEB Journal can read Dr. Clinton's original researchhere.
"Good Vibrations" May Prevent Bone Loss in Space -- NASA press release about the research featured in this article.
Space Bones -- Science@NASA article: Weightlessness sure looks like a lot of fun, but prolonged exposure to zero-G in space can have some negative side effects -- like the weakening of human bones!
Gravity Hurts (So Good)-- Science@NASA article: Strange things can happen to the human body when people venture into space -- and the familiar pull of gravity vanishes.
Dr. Clinton Rubin -- Professor, Chair of Department of Biomedical Engineering. SUNY Stony Brook.
National Space Biomedical Research Institute-- home page.
Q&A about osteoporosis-- from the American Medical Women's Association
Bone Loss research group-- webpage for the division of the National Space Biomedical Research Institute studying bone loss in space. Also has links to other divisions of NSBRI that deal with different medical issues related to space travel.
Prevention of Bone Loss During Manned Space Flight-- information about the Vanderbilt University research discussed in this article.
Sub-regional Assessment of Bone Loss-- fact sheet for an experiment on bone loss conducted on the International Space Station during Expedition Two. Information on this experiment from NASA's Johnson Space Center can also be found here .
Medical benefits of NASA research on bone loss-- information on how research to solve the mystery of bone loss in space helps to advance the treatment of osteoporosis.
A Boon for Bone Research-- a medical tool for measuring bone stiffness without using radiation was developed for researching bone loss in space, but it is also proving useful for diagnosing bone loss here on the ground.
Calcium Kinetics During Spaceflight-- technical information about how calcium is regulated in the body, both on the ground and in space. From NASA's Johnson Space Center.
Bone Function-- from the National Space Biomedical Research Institute.
Investigation of bone growth in space-- from the National Space Biomedical Research Institute.
Biotechnology research in microgravity-- from NASA's Marshall Space Flight Center
More links on osteoporosis-- from the National Aging Information Center
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