Aug 19, 2004

Have Blood, Will Travel


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Have Blood, Will Travel

The radiation astronauts encounter in deep space could put vital blood-making cells in jeopardy.





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August 19, 2004: In the time it takes you to read this sentence, more than 10 million red blood cells in your body will die. Don't be alarmed; it's natural, and stem cells in your bone marrow are constantly making enough new cells to replace the dying ones.

But what if those blood-making cells stopped working? Without a fresh supply of red and white blood cells, you would quickly become anemic, your immune system would collapse, and without medical attention, you would die.

This could be a concern for astronauts taking long trips beyond Earth orbit. It's well known that space radiation can damage cells in astronauts' bodies. Less well understood is the specific threat to the key blood-making cells.

Understanding that threat, and developing remedies, is the job of Alan Gewirtz, a medical doctor at the University of Pennsylvania (Division of Hematology and Oncology). He's bombarding stem cells with simulated space radiation to see how the cells are affected. By exploring the molecular damage, and testing candidate drug-remedies, "this research could benefit not only astronauts, but also people here on Earth who suffer from blood disorders such as leukemia and aplastic anemia," says Gewirtz.




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The work is being done at the NASA Space Radiation Laboratory ("NSRL" for short) in New York. NSRL draws high-speed particles from one of the atom smashers at Brookhaven National Laboratory in Long Island and channels them to a special facility for biological research. The radiation consists of protons and heavy ions moving at almost light speed--much like the cosmic rays astronauts encounter in deep space.

Apollo astronauts absorbed some cosmic rays on their way to the moon, but they didn't suffer much from it because those trips were short, a matter of days. Astronauts traveling to Mars, on the other hand, will be "out there" for at least six months. Accumulated cosmic ray damage could become important.

To see how cosmic rays affect an astronaut's internal blood supply, Gewirtz irradiates Petri dishes containing samples of blood-making stem cells. Each sample contains about a million cells collected from the bloodstream of paid, healthy volunteers. Once the cells have been exposed, the team looks closely for damage. Are the cells' DNA strands (the "memory chips" for making new cells) affected? If so, how, and how badly? Are other parts of the cells' internal machinery damaged? In what ways?


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These stem cells should not be confused with controversial embryonic stem cells: Gewirtz is working with adult stem cells.


Adult stem cells live in several places within every person's body, such as the bone marrow, the brain, the skin, and the gut. Unlike most of the body's cells, stem cells aren't pigeonholed into being only one kind of cell, such as a heart or a kidney cell; instead, they retain the ability to become any type of cell--a trait called "pluripotency" or "multipotency."

Left: Stem cells in the bone marrow can spawn any of a wide range of blood cell types. Image courtesy Stem Cell World.

Bone marrow stem cells, called "hematopoietic progenitor" cells, generate a continuous supply of cells that can become any of the following: platelets, lymphocytes and granulocytes (white blood cells), erythrocytes (red blood cells), and others. In this way, stem cells are a source of fresh replacement cells to fill in as older cells wear out.

Beyond assessing radiation damage to hematopoietic progenitor cells, Gewirtz's group also plans to test some drug-like "countermeasures" that could help astronauts better endure low levels of radiation exposure.

One idea is to give the cells antioxidants. Much of the damage to DNA isn't caused by the radiation itself, but by chemically reactive "free radicals" created when the radiation strikes some other molecule. These roving free radicals then go on to "oxidize", and thus damage, the DNA. Mopping up free radicals with antioxidants, in the form of pills, perhaps, could slow or halt the damage.


Right: Dr. Alan Gewirtz of the University of Pennsylvania Division of Hematology and Oncology. [More]


Another approach they're considering is to amplify a natural system in people's cells for repairing DNA. Normally, cells contain dozens of specialized repair enzymes that constantly run up and down the long, stringy DNA molecules, checking for damage and making repairs. "We hope to find ways to stimulate the natural repair mechanisms," Gewirtz says. "It's hard to beat millions of years of evolution for picking out what works, and works well."

Will these countermeasures help protect the cultured cell samples? Gewirtz says his team ought to have some results by the end of the year. If they're successful, astronauts on their way to Mars may not have to worry about their own internal wellsprings of new blood cells running dry.