1960s

1961: The U.S. Navy launches Transit IV-A, a test the first-of-its kind radioisotope power supply in space.
1969: NASA launches its first Radioisotope Thermoelectric Generator (RTG) aboard the Nimbus III weather satellite.
1969: Apollo 11 carries the first radioisotope power system to the Moon. All six Apollo lunar missions carry special long-term, radioisotope-powered science experiments called Apollo Lunar Surface Experiment Packages (ALSEPs).
1969: Nimbus III helps scientists track deadly Hurricane Camille.
1970s

1972: NASA retires the Nimbus III orbiter after a successful mission.
1976: NASA's Viking 1 and Viking 2 landers – powered by SNAP-19 RTGS – send back the first images and data from the surface of Mars.
1977: Taking advantage of a rare planetary alignment, NASA's twin Voyagers launch for the outer solar system. Their long voyages are powered by the Multi-Hundred Watt RTGs.
1977: Designed for a life of one year (Apollo 17 was designed for two), the Apollo Lunar Surface Experiments are powered down. Most of the knowledge of the lunar interior at the time came from ALSEPs.
1980s

1986: Voyager 2 becomes the first – and still the only – spacecraft to fly past Uranus.
1989: Voyager 2 becomes the first – and still the only – spacecraft to fly past Neptune.
1989: The Galileo orbiter – powered and heated by two General Purpose Heat Source RTGs (GPHS-RTGs) and 120 Radioisotope Heater Units (RHUs) – launches for Jupiter from the Space Shuttle Atlantis.
1990s

1990: NASA and ESA team up to launch the Ulysses orbiter on the first mission to study the heliosphere—the region of space influenced by the Sun and its magnetic field—from a unique solar polar orbit. The spacecraft is powered by a GPHS-RTG, which enabled the long, looping orbits required to explore the poles the Sun.
1994: Ulysses makes history as it makes the first pass by the poles of the Sun.
1996: Ulysses collects bonus science as it passes through the tail of comet Hyakutake. The spacecraft revealed comet tails are far longer than expected.
2000s

2003: Mars Exploration Rovers Spirit and Opportunity launch for the Red Planet. Both rovers are solar powered, but carried Radioisotope Heater Units (RHUs) to keep science instruments warm on the cold surface of Mars.
2004: Cassini becomes the first spacecraft to orbit Saturn. Three RTGs and 117 RHUs provide power and heat to the spacecraft.
2009: Ulysses ends its successful exploration of the polar regions of the Sun.
The breadth of science addressed by Ulysses is truly astonishing.The data acquired during the long lifetime of this mission have provided an unprecedented view of the solar activity cycle and its consequences and will continue to keep scientists busy for many years to come.

ed Smith
Ulysses Project Scientist
May 25, 2011: "Spirit" Rover Completes Mission on Mars
Spirit last communicated on March 22, 2010, as Martian winter approached and the rover's solar-energy supply declined. The rover operated for more than six years after landing in January 2004 for what was planned as a three-month mission. NASA checked frequently in recent months for possible reawakening of Spirit as solar energy available to the rover increased during Martian spring. A series of additional re-contact attempts ended today, designed for various possible combinations of recoverable conditions.
"Our job was to wear these rovers out exploring, to leave no unutilized capability on the surface of Mars, and for Spirit, we have done that," said Mars Exploration Rover Project Manager John Callas of NASA's Jet Propulsion Laboratory, Pasadena, Calif.
2010s

November 26, 2011: Curiosity Lifts Off
NASA began a historic voyage to Mars with the launch of the Mars Science Laboratory, which carries a car-sized rover named Curiosity. Liftoff from Cape Canaveral Air Force Station aboard an Atlas V rocket occurred at 10:02 a.m. EST (7:02 a.m. PST). The mission will pioneer precision landing technology and a sky-crane touchdown to place Curiosity near the foot of a mountain inside Gale Crater on Aug. 6, 2012.
August 5, 2012: Curiosity Lands on Mars
NASA's Mars Science Laboratory—the rover Curiosity—lands in Gale Crater. Its energy is provided by a radioisotope power system.
July 14, 2015: New Horizons Passes Pluto
NASA's New Horizons spacecraft becomes the first visitor from Earth to the Pluto system. Its long journey is made possible by an RTG power source.
September 15, 2017: Cassini's Grand Finale
NASA's Cassini spacecraft makes a fateful plunge into the atmosphere of Saturn, ending its 13-year tour of the ringed planet. Both Cassini and the Huygens probe were enabled by radioisotope heater units.
June 10, 2018: Opportunity's End of Mission
Designed to last just 90 Martian days and travel 1,100 yards (1,000 meters), Opportunity vastly surpassed all expectations in its endurance, scientific value and longevity. In addition to exceeding its life expectancy by 60 times, the rover traveled more than 28 miles (45 kilometers) by the time it reached its most appropriate final resting spot on Mars — Perseverance Valley.
January 1, 2019: New Horizons Passes Arrokoth
Arrokoth is located in the Kuiper Belt, beyond the orbit of Neptune. New Horizons flew just 2,200 miles (3,500 kilometers) from the object's surface, when it was about 4 billion miles (6.6 billion kilometers) from the Sun -- the most distant planetary flyby in history and the first close-up look at a solar system object of this type.
2020s

July 30, 2020: Mars Perseverance Rover Launches
Based on the same platform as the Curiosity Mars Rover, Perseverance will be looking for more evidence of past water on Mars.
February 18, 2021: Mars Perseverance Rover Lands on Mars
Perseverance, the Mars 2020 rover, landed in Jezero Crater to analyze and collect samples of Martian soil and rock.
2027: Dragonfly launches to Titan
NASA's Radioisotope Power System-enabled Dragonfly spacecraft is a drone that will land on and then fly around Saturn's largest moon, Titan, looking for clues to the moon's origins and for signs of life.
