OSDR – Data Processing
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Data Processing Overview
- Overview
- Bulk RNA Sequencing (RNA-seq)
- Single Cell RNA Sequencing (scRNA-seq)
- Amplicon Sequencing
- Metagenomics
- Platform-Specific Microarrays
- Methylation Sequencing (Methyl-seq)
GeneLab curates and processes a diverse range of omics data derived from model organisms exposed to spaceflight or space analog environments on Earth. To ensure accessibility, all associated metadata are meticulously curated, detailing experimental design, sample preparation, and study nuances. This curation process follows NASA’s Open-Source Science Initiative and the FAIR data principles, enabling seamless data interpretation, reuse, and cross-dataset analysis. GeneLab employs controlled vocabularies, ontologies, and the Investigation-Study-Assay (ISA) framework to maintain consistency and facilitate knowledge integration. The Biological Data Management Environment (BDME) further streamlines metadata submission, ensuring datasets meet quality standards before public release.
In parallel, GeneLab’s data processing team develops standardized bioinformatics pipelines to transform raw omics data into higher-level insights, such as gene expression changes. These consensus pipelines, created using open-source software, minimize variability across studies and are continuously updated to align with best practices. Processed data are published alongside raw data in the Open Science Data Repository (OSDR), with interactive visualization tools enhancing accessibility for a broad scientific audience. Additionally, GeneLab provides data processing services to NASA-funded investigators, supporting harmonized and reproducible analyses to advance space biology research.